Abstract： Objective To investigate the characteristics of symptom changes in adult brain glioma patients before and af-ter surgery,and to analyze the risk factors for symptom exacerbation.Methods A total of 81 patients with brain glioma who were treated in our hospital between October 2021 and February 2023 were selected in this study.The Chinese version of the M.D.Anderson Symptom Inventory-Brain Tumor Module(MDASI-BT)was applied to investigate the symptom clusters of patients before surgery,one week and one month after surgery,and to evaluate the severity of symptoms.Patients with a score of 5 or more were selected as the severe group,while those with a score of<5 were selected as the non-severe group.Univariate and binary Logistic regression analysis was conducted to screen for independent risk factors for symptom exacer-bation.Results In the general symptom clusters,the most prevalent symptom was distress,and the symptom with the high-est severity score was pain before surgery.One week after surgery,the assessment results showed that the most prevalent symptom was pain,while the symptom with the highest severity score was drowsiness.One month after surgery,the most preva-lent symptom was fatigue,and the symptom with the highest severity score was restlessness.In the symptom clusters specific to brain tumors,the most prevalent symptom before surgery was epilepsy,and the most severe symptom was difficulty in con-centrating.One week after surgery,the most prevalent symptom was difficulty in concentrating,and the most severe symptom was weakness on one side of the body.One month after surgery,the most prevalent symptom was diarrhea or constipation,and the most severe symptom was difficulty in concentrating.As for the interference items,among the general symptom clusters and the symptom clusters specific to brain tumors,the emotion of patients was interfered most before operation,one week after operation and one month after operation.Binary logistic regression analysis showed that family economic income of glioma pa-tients<60 000 RMB/year[OR=3.299,95%CI(1.103,9.872)],tumor pathological grade Ⅲ or Ⅳ[OR=3.349,95%CI(1.198,9.363)],and KPS score≤70 points[OR=3.234,95%CI(1.155,9.057)]were independent risk factors for symptom exacerba-tion(P<0.05).Conclusion Clinical nurses should tailor their interventions to the trajectory of symptom clusters in brain gli-oma patients at different stages of treatment,and pay special attention to patients at risk of symptoms exacerbation.