Abstract： Objective To observe the changes of retrobulbar hemodynamics in glaucoma patients after intraocular pressure(IOP)control and the effect of press-needle on retrobulbar hemodynamics.Methods A prospective,multicen-tre,randomised controlled clinical study was conducted on 192 glaucoma patients after IOP control,recruited from each centre,all the patients were randomly divided into the press-needle group and placebo-needle group.The press-needle group was treated with press-needle acupuncture,while the placebo-needle group with placebo-needle acupuncture.In-traocular pressure(IOP),best-corrected visual acuity(BCVA),peak systolic flow velocity(PSV),peak diastolic flow velocity(EDV),and resistance index(RI)of the ophthalmic artery(OA),central retinal artery(CRA),and short poste-rior ciliary artery(SPCA)were compared between the two groups before,2 months after,and 4 months after treatment.Results There were no statistically significant differences in IOP,BCVA,OA,CRA,and SPCA-related haemodynamic indices between the two groups before treatment(P＞0.05).At 2 and 4 months after treatment,the BCVA of the press-needle group was not significantly different from that before treatment(P＞0.05),However,BCVA in the placebo group was significantly lower than that before treatment(P＜0.05).At 2 and 4 months after treatment,There was no signifi-cant difference in IOP between the press-needle group and the placebo-needle group(P＞0.05).Compared with the tine of before treatment,PSV and EDV of OA,CRA and SPCA in the press-needle group were increased at 2 and 4 months after treatment(P＜0.05),RI decreased at 2 and 4 months after treatment(P＜0.05);However,2 months after treatment,RI in the placebo-needle group did not improve compared with that before treatment,and further increased after 4 months of treatment(P＜0.05);At 2 and 4 months after treatment,PSV and EDV in the placebo-needle group decreased(P＜0.05).Conclusion Glaucoma patients with IOP control have impaired retrobulbar haemodynamics,and the improvement of visual acuity in glaucoma patients with IOP control by press-needle may be caused by the improvement of retrobulbar haemodynamic changes.