Abstract： Objective To analyze the research status,hotspots and trends of age-related macular degeneration(AMD)based on VOSviewe and CiteSpace.Methods Retrieve AMD-related literature included in the China National Knowledge Infrastructure from its establishment to 2023,VOSviewer plots author collaboration networks,keyword co-occurrence mapping;CiteSpace plots institutional collaboration networks,keyword clustering,and emergence mapping.Results A total of 953 papers were included,involving 2254 authors and 483 institutions.The annual number of publica-tions showed an overall increasing trend,and some authors formed sizable class groups.The high-frequency keywords were AMD,wet AMD,ranibizumab,compazine,and choroidal neovascularization(top 5).Conclusion The research hotspot in this field mainly focuses on the observation of the clinical efficacy of vitreous cavity injection of anti-VEGF drugs in the treatment of wet AMD,and the research trend is gradually shifting to the experimental study of the pathogen-esis of AMD as well as the mechanism of Chinese and Western medicine in the treatment of AMD.