Epidemiological studies have shown that people who were exposed to Coal Tar Pitch (CTP) had a higher incidence of lung cancer than control population. In addition, CTP could induce two kinds of lung cancer in rats and mice. Although CTP is widely considered as a definite carcinogen, the mechanism of carcinogenesis is still unknown. Ohta discovered a new gene-FHIT (Fragile histidine triad) by exon-capture technique in 1996. It was reported that this gene was closely associated with the environmental carcinogen. FHIT gene is a focus for the study of environmental carcinogen acted upon. In our experiment, CTP was heated directly to produce fume to set an environment simulating workplace. Experimental mice were forced to inhale fume of CTP to induce model of lung cancer. Through series killing, the deletion of FHIT gene during tumor genesis was studied. The purpose of this study is to investigate whether the molecular genetic event can be used to detect primary lung cancer. It can also provide useful information

来源：癌变·畸变·突变 2001 年 13卷 4期