Objective::Current theories highlight the role of the microbiome in the pathogenesis of psoriasis. Additionally, abnormal metabolism can alter disease processes in terms of occurrence, progression, and prognosis. Therefore, an integrative microbiome and metabolome analysis of the skin may aid in understanding the disease pathogenesis and identify therapeutic targets for psoriasis.Methods::We recruited 22 patients with psoriasis and 22 age- and sex-matched healthy controls. Skin swabs were collected from the participants’ scalps. All samples underwent amplicon sequencing of the internal transcribed spacer 1 and V3V4 16S rRNA regions and metabolome analysis. For amplicon data, analysis of the alpha diversities, microbial community structures and principal coordinate analysis were performed. Differential metabolites and pathway enrichment were analyzed for metabolome data. Student t test and Wilcoxon rank sum test were used for statistical analysis. Results::The psoriatic lesions were characterized

作者：Tao Rong；Wan Zhe；Li Ruo-Yu；Wang Ruo-Jun

来源：国际皮肤性病学杂志（英文） 2023 年 06卷 4期