Background::Concerns exist regarding the potential development of tuberculosis in patients with rheumatoid arthritis (RA) treated with biological and targeted drugs. We assessed systematically whether biological therapy increased the risk of tuberculosis in patients with RA by meta-analysis of randomized controlled trials (RCTs).Methods::A systematic literature search was conducted in PubMed, Embase, the Cochrane Library, and China Biology Medicine disc for RCTs evaluating biological therapy in patients with RA from inception through August 2021. Traditional meta-analysis and network meta-analysis were performed to compare the risk of tuberculosis for each biologics class in patients with RA. Peto odds ratio (Peto OR) and its 95

作者：Ji Xiaojian；Hu Lidong；Wang Yiwen；Man Siliang；Liu Xingkang；Song Chuan；Zhang Jiaxin；Zhu Jian；Zhang Jianglin；Huang Feng

来源：中华医学杂志英文版 2022 年 135卷 4期