Background::Plasminogen activator inhibitor-1 (PAI-1) plays an important role in the pathophysiology of sepsis, but the exact mechanism remains debatable. In this study, we investigated the associations among the serum levels of PAI-1, the incidence of 4G/5G promoter PAI-1 gene polymorphisms, immunological indicators, and clinical outcomes in septic patients.Methods::A total of 181 patients aged 18-80 years with sepsis between November 2016 and August 2018 in the intensive care unit in the Xinhua Hospital were recruited in this retrospective study, with 28-day mortality as the primary outcome. The initial serum level of PAI-1 and the presence of rs1799768 single nucleotide polymorphisms (SNPs) were examined. Univariate logistic regression and multivariate analyses were performed to determine the factors associated with different genotypes of PAI-1, serum level of PAI-1, and 28-day mortality.Results::The logistic analysis suggested that a high serum level of PAI-1 was associated with the rs1799768 SNP of PAI-1

作者：Jiang Shaowei；Wang Yang；Chen Liang；Mu Honghua；Meaney Connor；Fan Yiwen；Pillay Janesh；Wang Hairong；Zhang Jincheng；Pan Shuming；Gao Chengjin

来源：中华医学杂志英文版 2023 年 136卷 16期